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No distinct dose adjustment encouraged when tofacitinib coadministered with powerful CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both equally moderate CYP3A4 and powerful CYP2C19 inhibitors .Impact of coadministration of the twin CYP3A4 and CYP2C19 inhibitor with fedratinib has not been researched.In vitro, modafinil continue